CBD with Melatonin: What You Need to Know Before Taking It

A lot of us take CBD for sleep, thanks to reports that it may help calm down the body and mind. 

As a result, today’s hemp industry offers a wide array of cannabidiol-infused products marketed specifically for bedtime use, in all kinds of formulas, delivery methods, strengths and more.

One of the most common categories of CBD sleep products is formulas that are enhanced with melatonin

Many people have been taking melatonin since long before the hemp industry first found its footing. 

But does that mean that anyone struggling with sleep should automatically opt for a melatonin-infused CBD product? 

Let’s find out.

What is the Primary Use of CBD Products with Melatonin?

What is the Primary Use of CBD Products with Melatonin?

Melatonin exists primarily as a sleep aid and isn’t really marketed toward any other purposes other than that. 

Therefore, CBD products that are infused with melatonin are strictly for bedtime use, in order to potentially support sleep. 

Both cannabidiol and melatonin have been studied for their sleep-regulating effects, which is why they’re so commonly paired together in all kinds of formulations.

Does Melatonin Work?

Does Melatonin Work?

Melatonin has the strong potential to help with sleep. 

It’s a naturally occurring hormone in the brain that controls our entire sleep cycle. 

We know that the neurotransmitters in the brain must maintain a certain level of balance in order for us to sleep properly each night. 

Melatonin is a key factor in this balance, as melatonin levels are supposed to naturally rise in the evening and dip in the morning when it’s time to wake up.

Many of us, however, can be deficient in melatonin. 

The most common reason is stress. 

When we are stressed, we produce higher levels of cortisol, a hormone that is an antagonist to melatonin. 

This is why many people can experience the “tired but wired” sensation when it is bedtime.

By taking melatonin as a nightly supplement, at least theoretically, we are bringing our hormones back to that ideal balance so that our sleep cycle can return to normal.  

In fact, there is a plethora of research indicating that melatonin is an effective solution for getting in 8 hours of sleep each night.

Does CBD Work for Sleep?

Does CBD Work for Sleep?

CBD is a unique type of compound that doesn’t force the body into a sleep state, but supports the natural mechanisms that regulate our inherent sleep cycles. 

It’s a cannabinoid, which means that it efficiently binds to cannabinoid receptors in the brain and nervous system which are in charge of regulating specific processes of the body, including sleep and mood. 

Multiple studies have even indicated that CBD may be able to promote better sleep each night. But we need further more concrete evidence before any definitive claims can be made surrounding CBD and sleep.

Can CBD and Melatonin Be Taken Together?

It’s understandable to wonder about what happens when you take these two compounds together, in order to avoid any potential for a negative interaction. 

As of now, there is zero evidence that taking these two compounds together puts you at any serious risk, generally speaking. 

A lot of hemp companies produce melatonin-infused CBD formulas, and these companies have done their research to ensure that their products are formulated to be as safe as possible.

Despite that, we still recommend that your first speak to your doctor before starting any regimen with CBD and melatonin.

What Kinds of CBD and Melatonin Products Exist on the Market?

If you’re looking to purchase a product that contains CBD and melatonin, knowing what options are available, and how each product type works in the body is crucial indeed.


CBD and Melatonin in Capsules

Typically contain only hemp extract, melatonin, and a carrier oil. 

They can take effect within 1 to 2 hours, and remain active for up to 8 hours, which is a good choice for someone who struggles to stay asleep throughout the night.


CBD and Melatonin in Tinctures

Consist of hemp extract and melatonin diluted in a carrier oil, just like capsules. 

The difference is that these products absorb through the sublingual tissue beneath the tongue, allowing them to take effect in as little as 20 minutes, while remaining effective for around 4 to 6 hours.


CBD and Melatonin in Edibles

Work like capsules, taking about 1 to 2 hours to take effect and lasting for up to 8 hours.

Other Important Factors to Consider

With numerous product types to select from, going about which one to take comes down to the following:

#1: Milligram Strength

All of the types of products listed above can be found in a variety of milligram strengths, thus determining the potency of both the CBD and the melatonin. 

Therefore, it’s important to pay attention to the strengths of each compound to know how strong the effects will be.

#2: Type of Hemp Extract

Any CBD product can be made with either full spectrum, broad spectrum or CBD isolate extract. 

CBD isolate is pure cannabidiol, while full spectrum contains every compound in the hemp plant, including a diverse array of cannabinoids, terpenes, nutrients and more. 

Broad spectrum hemp removes the trace amount of THC from the formula, but retains all of the other compounds. 

It’s possible that full spectrum CBD is the best for supporting sleep due to the presence of terpenes and other cannabinoids that can aid in the effectiveness.

Should Everyone Take CBD with Melatonin for Sleep?

Should Everyone Take CBD with Melatonin for Sleep?

Keep in mind that you should only take one of these products after speaking with your doctor. 

Your doctor knows your unique circumstances and can also take into account medications you are on that could potentially interact with either of these two compounds.

Ideally, the type of doctor you should speak to is a sleep specialist, a pulmonologist, or a neurologist. 

They can better understand the effects of melatonin and whether or not it is compatible for you.

Sleep doctors have knowledge when it comes to all sleeping disorders and can address hormonal imbalances and other causes behind sleeping troubles. 

They may direct you to one of the next two types of specialists.

Pulmonologists are doctors who deal with the respiratory system. 

Some sleep disorders are caused by respiratory issues such as sleep apnea, in which the patient actually stops breathing throughout the night.

Neurologists can help you with a sleeping disorder caused by an underlying neurological issue, such as epilepsy which is disruptive to a person’s sleep cycle.

The most common sleep disorder is sleep anxiety, meaning that anxiety symptoms become elevated at night. 

If this is an issue that you are experiencing, melatonin may be useful, but it’s not useful for everyone. 

Melatonin helps the body produce more of the hormone at night, but if the anxiety is severe enough, it can override melatonin’s effects. 

Therefore, you should consider an additional treatment for anxiety.


While CBD is not usually associated with any major side effects following a dose at night, melatonin may cause side effects in some people.  

The most common side effects associated with melatonin are:

  • Headache
  • Dizziness
  • Grogginess
  • Poor Cognitive Skills
  • Low Blood Pressure
  • Vivid Dreams

Obviously, higher doses can yield stronger side effects. 

If you are experiencing any of these side effects after taking melatonin, you may want to stop taking it altogether.

Melatonin should not be taken by anyone who has an autoimmune disorder. 

You cannot drive within 6 hours of taking melatonin, and certain medications can cause dangerous effects. 

Again, your doctor can give you personalized information to help you decide whether or not a melatonin-infused CBD product is right for you.

You should not consume melatonin if you are already taking a prescription medication for sleep, as this can have negative consequences in regard to the nervous system. 

It can slow down breathing to a dangerous rate and can leave you feeling cognitively impaired the next day.

And, if it turns out that melatonin is something that you should avoid, keep in mind that many people have success with hemp alone.

So feel free to continue with a nightly CBD routine minus the melatonin, should your doctor advise you to do so.

A Restful Combination That Could Be What You’re Looking For

CBD alone is incredibly useful for lots of common sleep-related issues but combining it with melatonin can ensure a better night’s sleep. 

Melatonin is a natural sleep aid that has been tested for its safety and effectiveness, but it still may not be suitable for everyone, especially if you have an underlying medical condition or you are taking other types of medications.

19th Jun 2022

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